In doing that, they are able to help ladies understand a potential link between life encounters and preterm birth risk. Although extensive research gives important new understanding about preterm birth, more answers are needed still. The researchers are actually exploring how the body can keep in mind traumatic events early in life in such a way that it affects health outcomes years later on. Olson believes that a high burden of demanding experiences in childhood may cause adjustments in how genes are expressed in afterwards life.Main safety end points included the rate of recurrence of adverse scientific or laboratory occasions and the transformation in bone mineral density. We graded adverse occasions based on the National Institutes of Wellness Division of AIDS Desk for Grading the severe nature of Adult and Pediatric Adverse Occasions . All analyses were performed by using SAS software, version 9.2 . Although one-sided checks were utilized for sample-size calculations, we utilized two-sided assessments for all final analyses. P ideals of significantly less than 0.05 were considered to indicate statistical significance. Outcomes Study Participants We screened 2533 volunteers; 52.2 percent were eligible for enrollment. The primary known reasons for ineligibility were abnormal laboratory test results , especially hyperamylasemia , hyperbilirubinemia , and positivity for hepatitis B virus surface antigen ; not really being sexually active ; and HIV infection .