But his work has also found an increased level of activity of CYP1A2 in women who both smoke and drink caffeine. The effects of large amounts of caffeine in the long term remain being investigated but it has been associated with cardiac issues in old age, while increased CYP1A2 activity has been linked to several cancers. The latest Australian Bureau of Figures figures indicate as many as 9 % of young ladies between the age range of 15 and 24 smoke regularly..Today announced an exclusive worldwide licensing contract that will add two distinctive nucleotide analogues to Vertex’s hepatitis C portfolio. The compounds, that have been discovered by Alios and so are known as ALS-2200 and ALS-2158, show in in vitro research to be potent inhibitors of the hepatitis C virus polymerase, an enzyme needed for replication of the virus. The addition of these substances provides Vertex with multiple opportunities to build up potential, new, all-oral combination regimens for persistent hepatitis C. Vertex expects ALS-2200 and ALS-2158 to enter clinical development this year later.