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The ultrasonography-confirmed medical diagnosis offered as the deep-vein thrombosis element of the primary outcome. The secondary safety outcome was the rate of major mechanical complications during insertion of the central venous catheter and follow-up. Mechanical problems were defined in accordance with the modified National Cancer Institute Common Terminology Requirements for Adverse Events, version 4.0 , with the modification that pneumothorax requiring chest-tube insertion was classified as quality 3 rather than grade 2. Statistical Evaluation Our sample-size estimation is described in the Supplementary Appendix. We estimated that a total sample of 3333 catheters was required, provided our preliminary assumptions about the incidence of catheter-related complications. The statistical unit of analysis was the catheter.