These results suggest that 5-HT2A antagonists/inverse agonists, such as pimavanserin, could be effective in the treating patients with ADP. ADP represents a major unmet medical need with no proven safe and effective therapy, said Uli Hacksell, Ph.D., ACADIA’s LEADER Officer. Physicians often holiday resort to off-label use of antipsychotic medications in individuals with ADP despite their association with increased mortality and potential worsening of cognitive disturbances.Mesothelioma is a particularly lethal type of cancer that’s usually caused because of exposure to asbestos. Most patients who develop mesothelioma have a history of working in industries where there was a risk of asbestos publicity, such as shipping, mining or insulation. Mesothelioma occurs decades after publicity. Professor Hilary Calvert, of the Northern Institute of Cancers Research, University of Newcastle upon Tyne, comments, This form of cancer is usually diagnosed at an advanced stage at which stage treatment with radiation therapy or surgery treatment isn’t an option. Most of the individuals I see only have a life span after diagnosis of only a matter of months. He adds, As yet there’s been no licenced chemotherapy available and patients have already been more likely to have treatment aimed to alleviate the symptoms instead of to control the condition.